The Joint Royal Colleges Ambulance Liaison Committee Clinical Guidelines are the essential clinical guideline resource for paramedics. The guidelines are written specifically for ambulance serviceO paramedics, combining evidence-based practice with expert advice and practical guidance. They provide a comprehensive overview of the many clinical conditions paramedics care for, and support them in providing excellent patient care.aThis 2025 edition has been updated with the latest evidence and developments inaclinical practice. Key reviews have taken place on guidelines within theaMaternity section, as well as updates to Medical guidelines such as Seizures in Adults and Children, and Pain Management. Medicine guidelines have been removed,abut are available on the iCPG and JRCALC Plus apps, where they are regularly updatedato ensure that the most up-to-date guidance is available to clinicians when providing direct patient care.aThe JRCALC Clinical Guidelines 2025 now contains crucial guidance on topics,aincluding:O Behavioural EmergenciesO Clinical Considerations in Relation to Diversity and EqualityO Conditions Requiring Specific Prehospital Clinical ManagementO DrowningO Overdose and PoisoningO Seizures