Depression and physical illness are intimately related. Depressed mood is thought to contribute to the development and progression of some illnesses, while physical illness can in turn increase the risk of depression. This book provides a critical overview of the evidence linking depression with several major health conditions, including coronary heart disease, diabetes, cancer, chronic pain, disability, chronic fatigue and obesity. It also explores the biological and behavioural processes underlying the association, discussing the role of neuroendocrine, immunological and inflammatory pathways, and the relationship between depression and health behaviours such as smoking, physical activity and adherence to medical advice. It combines a thorough analysis of the clinical, biological and epidemiological data with guidance to health professionals and patients on how to manage depression in people suffering from physical illness, pointing the way to an integrated approach to health care.
Part I. Introduction to Depression and its Determinants: 1. Depression in the medically ill Francis Creed and Chris Dickens; 2. Psychosocial factors, depression and illness Stephen Stansfeld and Farhat Rasul; Part II. Depression and Specific Health Problems: 3. Depression and the development of coronary heart disease Andrew Steptoe; 4. Depression and prognosis in cardiac patients Heather Lett, Andrew Sherwood, Lana Watkins and James Blumenthal; 5. The management of depression in patients with coronary heart disease Robert Carney and Kenneth Freedland; 6. Depression and physical disability Brenda Penninx; 7. Chronic pain and depression: twin burdens of adaptation Christina Van Puymbroeck, Alex Zautra and Peter-Panagioti Harakas; 8. The interrelationship of depression and diabetes Dominique L. Musselman, Angela Bowling, Natalie Gilles, Hannah Larsen, Ephi Betan and Lawrence S. Phillips; 9. Depression and chronic fatigue Peter D. White; 10. Cancer and depression Alice E. Simon, Steven C. Palmer and James C. Coyne; 11. Depression and obesity Lucy Cooke and Jane Wardle; Part III. Biological and behavioural processes; 12. Inflammation, sickness behaviour, and depression Robert Dantzer, Nathalie Castanon, Jacques Lestage, Maite Moreau and Lucile Capuron; 13. The hypothalamic-pituitary-adrenal axis: cortisol, DHEA, mental and behavioural function Ian Goodyer; 14. Depression and immunity: biological and behavioral mechanisms Michael Irwin; 15. Smoking and depression Jon D. Kassel and Benjamin L. Hankin; 16. Depression and physical activity Andrew Steptoe; 17. Adherence to medical advice Douglas A Raynor, Rena R. Wing and Suzanne Phelan; Part IV. Conclusions: 18. Integrating clinical with biobehavioural studies of depression and illness Andrew Steptoe.
